Preheat the oven to 400F and line a baking sheet with parchment paper. Then, chop up a large head of cauliflower into bite sized pieces. Add the chopped cauliflower to the parchment lined tray.
Next, drizzle ¼ cup of the buffalo sauce, the oil, garlic powder, salt, and pepper on top of the cauliflower and toss together until evenly coated. Reserve the remaining ¼ cup of buffalo sauce to pour on after baking. If you prefer, the cauliflower and sauce ingredients can also be mixed together in a large bowl and then added to the baking tray.
Then, add the tray of cauliflower to the oven and bake for 30 minutes until the cauliflower is baked through and beginning to crisp. I recommend tossing the cauliflower halfway through baking to make sure it bakes evenly.
Remove the tray of baked cauliflower from the oven and pour oven the remaining ¼ cup of buffalo sauce right away. Then, toss the cauliflower with the buffalo sauce until evenly coated and set aside.